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Are you aware of the continuing risk of septic transfusion reactions?

Patient safety comes first. Take no chances with platelet transfusions.

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If you are not ensuring complete elimination of contaminating bacteria there will always be the risk of transfusion transmitted bacterial infection through platelet components and the chance of a septic transfusion reaction.

Given that transfusion transmitted bacterial infection and septic transfusion reaction remain the principle causes of mortality related to transfusion1, we thought it is our duty to address this blood safety risk in greater depth.

We aim to bring you up to date with the latest, most relative insights on:

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You can receive our highlights by subscribing to our newsletter.

  1. United States Government Food & Drug Administration (FDA). Fatalities reported to FDA following blood collection and transfusion: Annual summary for FY 2017.
  2. Hong H, Xiao W, Lazarus HM, Good CE, Maitta RW, Jacobs MR. Detection of septic transfusion reactions to platelet transfusions by active and passive surveillance.  2016;127(4):496-502.
  3. Benjamin R.; Transfusion-related sepsis: a silent epidemic; Blood, 2016; Volume 127, Number 4
  4. Domanovic D.; Prioritizing of bacterial infections transmitted through substances of human origin in Europe; Transfusion 2017;57;1311–1317 
  5. White K.; Bacterial contamination rate of platelet components by primary culture: a systematic review and meta-analysis; Transfusion 2020;60;986–996
  6. Walker S.; Residual bacterial detection rates after primary culture as determined by secondary culture and rapid testing in platelet components: A systematic review and meta-analysis, Transfusion. 2020;60:2029–2037.
  7. Summary of the 2020 annual reporting of serious adverse reactions and events for blood and blood components; European Commission, Directorate-general for health and food safety.
  8. Eke PI, Thornton-Evans GO, Wei L, Borgnakke WS, et al. Periodontitis in US adults: National Health and Nutrition Examination Survey 2009-2014. J Am Dental Assoc 2018; 149: 576-88
  9. Christian Damgaard, Susanne G. Sækmose, Martin Nilsson, Mogens Kilian: Periodontitis increases risk of viable bacteria in freshly drawn blood donations. Blood Transfus 2021; DOI: 10.2450/2021.0336-20
  10. Summary of the 2011 - 2020 annual reporting of serious adverse reactions and events for blood and blood components; European Commission, Directorate-general for health and food safety.
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